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NFL Leaders |
Sacks
| Rank | Name | Team | G | TK | Sacks | Sack-Yds | Int | Fum | PD |
| 1 | C. Jones | Ari | 16 | 59 | 17.0 | 113.0 | 0 | 2 | 3 |
| 2t | C. Campbell | Jax | 16 | 67 | 14.5 | 96.0 | 0 | 3 | 3 |
| 2t | D. Lawrence | Dal | 16 | 58 | 14.5 | 160.0 | 0 | 4 | 1 |
| 4t | E. Griffen | Min | 15 | 45 | 13.0 | 76.0 | 0 | 3 | 1 |
| 4t | C. Jordan | NO | 16 | 62 | 13.0 | 93.5 | 1 | 2 | 11 |
| 4t | R. Kerrigan | Was | 16 | 46 | 13.0 | 73.5 | 1 | 3 | 1 |
| 7 | J. Bosa | LAC | 16 | 70 | 12.5 | 66.0 | 0 | 4 | 1 |
| 8t | E. Ansah | Det | 14 | 44 | 12.0 | 75.0 | 0 | 1 | 0 |
| 8t | C. Heyward | Pit | 15 | 45 | 12.0 | 71.0 | 0 | 2 | 3 |
| 8t | Y. Ngakoue | Jax | 16 | 30 | 12.0 | 85.0 | 0 | 6 | 0 |
| 11t | M. Addison | Car | 16 | 44 | 11.0 | 70.5 | 0 | 2 | 1 |
| 11t | A. Donald | LAR | 14 | 41 | 11.0 | 95.0 | 0 | 5 | 1 |
| 11t | J. Peppers | Car | 16 | 33 | 11.0 | 61.0 | 0 | 2 | 0 |
| 11t | T. Suggs | Bal | 16 | 49 | 11.0 | 71.5 | 0 | 4 | 4 |
| 15t | M. Ingram | LAC | 16 | 56 | 10.5 | 87.5 | 0 | 1 | 1 |
| 15t | K. Mack | Oak | 16 | 78 | 10.5 | 75.5 | 0 | 1 | 3 |
| 15t | C. Wake | Mia | 16 | 36 | 10.5 | 72.0 | 0 | 0 | 0 |
| 18 | V. Miller | Den | 16 | 57 | 10.0 | 64.5 | 0 | 2 | 3 |
| 19t | A. Clayborn | Atl | 16 | 21 | 9.5 | 61.5 | 0 | 2 | 0 |
| 19t | J. Clowney | Hou | 16 | 59 | 9.5 | 67.0 | 0 | 2 | 2 |
| 19t | B. Graham | Phi | 15 | 47 | 9.5 | 67.5 | 0 | 2 | 2 |
| 19t | J. Houston | KC | 15 | 59 | 9.5 | 54.0 | 0 | 0 | 5 |
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